Mechanisms underlying the association between adverse childhood experiences and racial disparities in later-life cognition.

ABSTRACT:

Objective

Adverse childhood experiences (ACEs) may be a risk factor for later-life cognitive disorders such as dementia; however, few studies have investigated underlying mechanisms, such as cardiovascular health and depressive symptoms, in a health disparities framework.

Method

418 community-dwelling adults (50% nonHispanic Black, 50% nonHispanic White) aged 55+ from the Michigan Cognitive Aging Project retrospectively reported on nine ACEs. Baseline global cognition was a z-score composite of five factor scores from a comprehensive neuropsychological battery. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Cardiovascular health was operationalized through systolic blood pressure. A mediation model controlling for sociodemograp

SUBMITTER: Wilhoite SR 

PROVIDER: S-EPMC11008525 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature