Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease.

ABSTRACT:

Background

Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention.

Purpose

The purpose of this analysis was to identify putative genetic variants associated with dropout from exercise training interventions among individuals in the STRRIDE trials.

Methods

We used a genome-wide association study approach to identify genetic variants in 603 participants initiating a supervised exercise intervention. Exercise intervention dropout occurred when a subject withdrew from further participation in the study or was otherwise lost to follow-up.

Results

Exercise intervention dropout was associated with a cluster of single-nucleotide polymorphisms with the top candidate being rs722069 (T/C, risk allele = C) (unadjusted p

SUBMITTER: Jiang R 

PROVIDER: S-EPMC11008589 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature