Systemic low-grade C-reactive protein is associated with proximal symptom spread in carpal tunnel syndrome.

ABSTRACT:

Introduction

Neuropathic pain is a highly prevalent condition associated with persistent disability. Some patients with neuropathic pain experience symptom spread outside neuroanatomical boundaries; these patients report more severe sensory symptoms and greater disability. However, the mechanisms behind such symptom spread are not fully understood.

Objective

We used pre-surgical carpal tunnel syndrome (CTS) as a human model system of neuropathic pain to identify differences in the concentration of serologic inflammatory mediators between patients with CTS with territorial symptoms and those with proximal symptom spread to either the elbow or shoulder/neck.

Methods

We performed a post-hoc analysis, comparing levels of serologic inflammatory mediators in a discovery coh

SUBMITTER: Zvonickova K 

PROVIDER: S-EPMC11008662 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature