Association of Biological Age with Tumor Microenvironment in Patients with Esophageal Adenocarcinoma.

ABSTRACT:

Introduction

Esophageal cancer is the seventh most common cancer worldwide and typically tends to manifest at an older age. Marked heterogeneity in time-dependent functional decline in older adults results in varying grades of clinically manifest patient fitness or frailty. The biological age-related adaptations that accompany functional decline have been shown to modulate the non-malignant cells comprising the tumor microenvironment (TME). In the current work, we studied the association between biological age and TME characteristics in patients with esophageal adenocarcinoma.

Methods

We comparatively assessed intratumoral histologic stroma quantity, tumor immune cell infiltrate, and blood leukocyte and thrombocyte count in 72 patients stratified over 3 strata of biological

SUBMITTER: Ravensbergen C 

PROVIDER: S-EPMC11008718 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature