Estimating the Distribution of True Rates of Visual Field Progression in Glaucoma.

ABSTRACT:

Purpose

The purpose of this study was to estimate the distribution of the true rates of progression (RoP) of visual field (VF) loss.

Methods

We analyzed the progression of mean deviation over time in series of ≥ 10 tests from 3352 eyes (one per patient) from 5 glaucoma clinics, using a novel Bayesian hierarchical Linear Mixed Model (LMM); this modeled the random-effect distribution of RoPs as the sum of 2 independent processes following, respectively, a negative exponential distribution (the "true" distribution of RoPs) and a Gaussian distribution (the "noise"), resulting in a skewed exGaussian distribution. The exGaussian-LMM was compared to a standard Gaussian-LMM using the Watanabe-Akaike Information Criterion (WAIC). The random-effect distributions were compared to the e

SUBMITTER: Montesano G 

PROVIDER: S-EPMC11008752 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature