TPMA: A two pointers meta-alignment tool to ensemble different multiple nucleic acid sequence alignments.

ABSTRACT: Accurate multiple sequence alignment (MSA) is imperative for the comprehensive analysis of biological sequences. However, a notable challenge arises as no single MSA tool consistently outperforms its counterparts across diverse datasets. Users often have to try multiple MSA tools to achieve optimal alignment results, which can be time-consuming and memory-intensive. While the overall accuracy of certain MSA results may be lower, there could be local regions with the highest alignment scores, prompting researchers to seek a tool capable of merging these locally optimal results from multiple initial alignments into a globally optimal alignment. In this study, we introduce Two Pointers Meta-Alignment (TPMA), a novel tool designed for the integration of nucleic acid sequence alignments. TPMA e

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC11008887 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature