Defining Ultra-Massive Transfusion through a Systematic Review.

ABSTRACT:

Background

Despite the widespread use of ultra-massive transfusion (UMT) as an intervention for trauma patients in hemorrhagic shock, no standard definition exists. We performed a systematic review to determine a consensus definition for UMT.

Methods

A search was performed from 1979-2022. The authors screened studies defining UMT and associated outcomes as defined by our prespecified PICO questions. The PRISMA guidelines were used.

Results

1662 articles met criteria for eligibility assessment, 17 for full-text review and eight for data extraction. Only two studies demonstrated a consensus definition of UMT, which used ≥20 units of red blood cell product within 24hrs. Parameters associated with increased mortality included lower blood pressure, lower pulse and l

SUBMITTER: Meyer CH 

PROVIDER: S-EPMC11008908 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature