Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.

ABSTRACT: Natural products have been playing indispensable roles in the development of lifesaving drug molecules. They are also valuable sources for covalent protein modifiers. However, they often are scarce in nature and have complex chemical structures, which are limiting their further biomedical development. Thus, natural product-inspired small molecules which still contain the essence of the parent natural products but are readily available and amenable for structural modification, are important and desirable in searching for lead compounds for various disease treatment. Inspired by the complex and diverse ent-kaurene diterpenoids with significant biological activities, we have created a synthetically accessible and focused covalent library by incorporating the bicyclo[3.2.1]octane α-meth

SUBMITTER: Liang W 

PROVIDER: S-EPMC11008911 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature