Antibacterial and antioxidant bifunctional hydrogel based on hyaluronic acid complex MoS₂-dithiothreitol nanozyme for treatment of infected wounds.

ABSTRACT: Wound repair is a complex physiological process that often leads to bacterial infections, which significantly threaten human health. Therefore, developing wound-healing materials that promote healing and prevent bacterial infections is crucial. In this study, the coordination interaction between sulfhydryl groups on dithiothreitol (DTT) and MoS₂ nanosheets is investigated to synthesize a MoS₂-DTT nanozyme with photothermal properties and an improved free-radical scavenging ability. Double-bond-modified hyaluronic acid is used as a monomer and is cross-linked with a PF127-DA agent. PHMoD is prepared in coordination with MoS₂-DTT as the functional component. This hydrogel exhibits antioxidant and antibacterial properties, attributed to the catalytic activity

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11009022 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature