Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials.

ABSTRACT:

Background and aims

Total abstinence has historically been the goal of treatment for substance use disorders; however, there is a growing recognition of the health benefits associated with reduced use as a harm reduction measure in stimulant use disorders treatment. We aimed to assess the validity of reduced stimulant use as an outcome measure in randomized controlled trials (RCTs) of pharmacological interventions for stimulant use disorder.

Design

We conducted a secondary analysis of a pooled dataset of 13 RCTs.

Setting and participants

Participants were individuals seeking treatment for cocaine or methamphetamine use disorders (N = 2062) in a wide range of treatment facilities in the United States.

Measurements

We validated reduced stimulant use against a set

SUBMITTER: Amin-Esmaeili M 

PROVIDER: S-EPMC11009085 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature