The influence of APOE status on rate of cognitive decline.

ABSTRACT:

Background

Apolipoprotein (APOE) ɛ4 positivity and subjective cognitive decline (SCD) both increase risk of Alzheimer's disease (AD) development. However, few studies have examined the relationship between SCD and APOE status, especially using longitudinal data. The current study examined whether APOE is associated with the rate of cognitive change in SCD and mild cognitive impairment (MCI).

Methods

A sample of 3494 older adults (1990 normal controls, NC, 775 SCD, and 729 MCI) with a mean follow-up of 9.09 years were included from the Rush Alzheimer's Disease Center Research Sharing Hub. Linear mixed effects models examined the relationship between APOE status and cognitive change in older adults with SCD normal controls, and people with MCI.

Results

The presence of a

SUBMITTER: Morrison C 

PROVIDER: S-EPMC11009190 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature