A variant in the 5'UTR of ERBB4 is associated with lifespan in Golden Retrievers.

ABSTRACT: Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated with Alzheimer's disease and cardiovascular disease, the latter being the most common cause of mortality in people worldwide. In contrast, naturally occurring cancer represents the leading cause of death in pet dogs, and specific breeds like the Golden Retriever (GR) carry up to a 65% cancer-related death rate. We hypothesized that GWAS of long-lived GRs might lead to the identification of genetic variants capable of modifying longevity within this cancer-predisposed breed. A GWAS was performed comparing GR dogs ≥ 14 years to dogs dying prior to age 12 which revealed a significant association to ERBB4, the only member of the epidermal growth factor receptor family capabl

SUBMITTER: Rebhun RB 

PROVIDER: S-EPMC11009206 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature