Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue.

ABSTRACT: The aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation of immune cell populations, serving as a major driver of age-associated adipose dysfunction and metabolic diseases. Conversely, the elimination of senescent ASPCs is associated with improvements in overall health. Intermittent fasting (IF), a dietary intervention that incorporates periodic cycles of fasting and refeeding, has been reported to promote weight loss and fat mass reduction and improve glucose and insulin homeostasis in both murine and human studies. While previous studies have assessed the effects of IF on obesity-associated metabolic dysfunction, few studies have examined the aging-specific changes to ASPCs and immune cell populations in WAT. Here, we show

SUBMITTER: Ealey KN 

PROVIDER: S-EPMC11009208 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature