Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.

ABSTRACT: While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudate nucleus and anterior cingulate cortex in post-mortem tissue from fifty-eight individuals with or without ADHD. While no single probe showed adjusted significance in differential methylation, several differentially methylated regions emerged. These regions implicated genes involved in developmental processes including neurogenesis and the differentiation of oligodendrocytes and glial cells. We demonstrate a significant association between differentially methylated genes in the caudate and genes implicated by GWAS not only in ADHD but also in autistic s

SUBMITTER: Shastri GG 

PROVIDER: S-EPMC11009227 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature