An adaptive biomolecular condensation response is conserved across environmentally divergent species.

ABSTRACT: Cells must sense and respond to sudden maladaptive environmental changes-stresses-to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures known as stress granules under severe stress. The composition, formation mechanism, adaptive significance, and even evolutionary conservation of these condensed structures remain enigmatic. Here we provide a remarkable view into stress-triggered condensation, its evolutionary conservation and tuning, and its integration into other well-studied aspects of the stress response. Using three morphologically near-identical budding yeast species adapted to different thermal environments and diverged by

SUBMITTER: Keyport Kik S 

PROVIDER: S-EPMC11009240 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature