Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population.

ABSTRACT: Coronavirus disease 2019 (COVID-19) was considered a major public health burden worldwide. Multiple studies have shown that susceptibility to severe infections and the development of long-term symptoms is significantly influenced by viral and host factors. These findings have highlighted the potential of host genetic markers to identify high-risk individuals and develop target interventions to reduce morbimortality. Despite its importance, genetic host factors remain largely understudied in Latin-American populations. Using a case-control design and a custom next-generation sequencing (NGS) panel encompassing 81 genetic variants and 74 genes previously associated with COVID-19 severity and long-COVID, we analyzed 56 individuals with asymptomatic or mild COVID-19 and 56 severe and critical

SUBMITTER: Angulo-Aguado M 

PROVIDER: S-EPMC11009356 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature