Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges.

ABSTRACT: Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect of sensory flicker exposure on local fi

SUBMITTER: Blanpain LT 

PROVIDER: S-EPMC11009358 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature