Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.

ABSTRACT: Stable matching of neurotransmitters with their receptors is fundamental to synapse function and reliable communication in neural circuits. Presynaptic neurotransmitters regulate the stabilization of postsynaptic transmitter receptors. Whether postsynaptic receptors regulate stabilization of presynaptic transmitters has received less attention. Here, we show that blockade of endogenous postsynaptic acetylcholine receptors (AChR) at the neuromuscular junction destabilizes the cholinergic phenotype in motor neurons and stabilizes an earlier, developmentally transient glutamatergic phenotype. Further, expression of exogenous postsynaptic gamma-aminobutyric acid type A receptors (GABA_A receptors) in muscle cells stabilizes an earlier, developmentally transient GABAergic motor neuron

SUBMITTER: Godavarthi SK 

PROVIDER: S-EPMC11009644 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature