Transcription factor C/EBPα is required for the development of Ly6C^hi monocytes but not Ly6C^lo monocytes.

ABSTRACT: Monocytes comprise two major subsets, Ly6C^hi classical monocytes and Ly6C^lo nonclassical monocytes. Notch2 signaling in Ly6C^hi monocytes triggers transition to Ly6C^lo monocytes, which require Nr4a1, Bcl6, Irf2, and Cebpb. By comparison, less is known about transcriptional requirements for Ly6C^hi monocytes. We find transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) is highly expressed in Ly6C^hi monocytes, but down-regulated in Ly6C^lo monocytes. A few previous studies described the requirement of C/EBPα in the development of neutrophils and eosinophils. However, the role of C/EBPα for in vivo monocyte development has not been understood. We deleted the Cebpa +37 kb

SUBMITTER: Kim S 

PROVIDER: S-EPMC11009651 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature