RAC1 as a potential pan-cancer diagnostic, prognostic, and immunological biomarker.

ABSTRACT:

Background

Ras-related C3 botulinum toxin substrate 1 (RAC1) is an important member of the Rho GTPase family involved in tumorigenesis. However, its role and potential clinical utility across cancer entities in solid tumors is unknown.

Methods

We analyzed data from various databases, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression Project, cBioPortal, Tumor Immune Estimation Resource 2 (TIMER2), and published articles. A prognostic nomogram for liver hepatocellular carcinoma (LIHC) patients was developed based on RAC1-guanosine triphosphate (GTP) gene expression levels, which were validated using immunohistochemistry (IHC).

Results

In this study, RAC1 was highly expressed in most cancers and correlated with prognosis and pathological

SUBMITTER: Tao L 

PROVIDER: S-EPMC11009796 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature