CCND2 is a prognostic biomarker and correlates with immune infiltration in lung adenocarcinoma.

ABSTRACT:

Background

CCND2 expression influences the growth and proliferation of cancer cells and plays a crucial role in immune response of tumor. However, few studies focused on the correlation between CCND2 and lung adenocarcinoma (LUAD) in terms of prognosis and tumor immune infiltration.

Methods

Original LUAD case data were screened from The Cancer Genome Atlas (TCGA) database. Using R software, we analyzed differently expressed CCND2 between LUAD and adjacent normal tissues. Kaplan-Meier analysis was conducted to determine the relationship between CCND2 expression and the overall survival of LUAD patients, and Cox regression analysis was performed to identify the independently prognostic risk factors for LUAD. Using TIMER (Tumor Immune Estimation Resource) and CIBERSORTx (Cell-t

SUBMITTER: Jia E 

PROVIDER: S-EPMC11009805 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature