Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study.

ABSTRACT:

Background

It is unclear how metabolic syndrome (MetS) and diabetes affect Gal-3 (galectin 3) levels and the resulting implications for heart failure (HF) risk. We assessed relationships of MetS and diabetes with Gal-3, and their joint associations with incident HF.

Methods and results

We included 8445 participants without HF (mean age, 63 years; 59% men; 16% Black race) at ARIC (Atherosclerosis Risk in Communities) study visit 4 (1996-1999). We categorized participants as having MetS only, MetS with diabetes, or neither, and by quartiles of MetS severity Z score. We assessed cross-sectional associations of metabolic risk categories with high Gal-3 level (≥75th percentile) using logistic regression. We used Cox regression to evaluate combined associations of metabolic

SUBMITTER: Echouffo-Tcheugui JB 

PROVIDER: S-EPMC11010020 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature