Age and Aspirin Dosing in Secondary Prevention of Atherosclerotic Cardiovascular Disease.

ABSTRACT:

Background

In patients with atherosclerotic cardiovascular disease, increasing age is concurrently associated with higher risks of ischemic and bleeding events. The objectives are to determine the impact of aspirin dose on clinical outcomes according to age in atherosclerotic cardiovascular disease.

Methods and results

In the ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) trial, patients with atherosclerotic cardiovascular disease were randomized to daily aspirin doses of 81 mg or 325 mg. The primary effectiveness end point was death from any cause, hospitalization for myocardial infarction, or hospitalization for stroke. The primary safety end point was hospitalization for bleeding requiring transfusion. A total of 15 076

SUBMITTER: Marquis-Gravel G 

PROVIDER: S-EPMC11010083 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature