Multiorgan Dysfunction and Associated Prognosis in Transthyretin Cardiac Amyloidosis.

ABSTRACT:

Background

Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive and ultimately fatal cardiomyopathy. Biomarkers reflecting multiorgan dysfunction are of increasing importance in patients with heart failure; however, their significance in ATTR-CA remains largely unknown. The aims of this study were to characterize the multifaceted nature of ATTR-CA using blood biomarkers and assess the association between blood biomarkers and prognosis.

Methods and results

This is a retrospective cohort study of 2566 consecutive patients diagnosed with ATTR-CA between 2007 and 2023. Anemia (39%), high urea (52%), hyperbilirubinemia (18%), increased alkaline phosphatase (16%), increased CRP (C-reactive protein; 27%), and increased troponin (98.2%) were common findings in the overall po

SUBMITTER: Ioannou A 

PROVIDER: S-EPMC11010096 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature