Minocycline in Severe Cerebral Amyloid Angiopathy: A Single-Center Cohort Study.

ABSTRACT:

Background

Evidence from animal studies suggests that minocycline may reduce lobar intracerebral hemorrhage (ICH) recurrence in cerebral amyloid angiopathy, possibly by inhibiting perivascular extracellular matrix degradation in cerebral small vessels. There is currently no evidence of its safety or efficacy in humans with cerebral amyloid angiopathy.

Methods and results

To provide preliminary data to support future studies of minocycline's efficacy, the authors performed a retrospective single-center cohort study to assess the incidence of recurrent ICH in patients with an aggressive clinical course of probable cerebral amyloid angiopathy who had been prescribed minocycline off-label via shared decision-making. Crude incidence rate ratios were calculated to compare incidenc

SUBMITTER: Bax F 

PROVIDER: S-EPMC11010112 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature