FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.

ABSTRACT:

Objective

Ferritin heavy chain 1 (FTH1) is an important subunit of ferro-storing proteins and is indispensable for iron metabolism. Though it has been extensively studied in numerous organs and diseases, the relationship between FTH1 and osteoarthritis (OA) is unclear.

Design

Primary murine chondrocytes and cartilage explants were treated with FTH1 siRNA for 72 h. Mice were injected with adenovirus expressing FTH1 after destabilized medial meniscus (DMM) surgery. These approaches were used to determine the effect of FTH1 expression on the pathophysiology of OA.

Results

FTH1 expression was down regulated in OA patients and mice after DMM surgery. Knock down of FTH1 induced articular cartilage damage and extracellular matrix degradation in cartilage explants. Further, o

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC11010333 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature