Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow.

ABSTRACT:

Background

In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer's disease (AD) have an increased prevalence of epileptiform discharges and a study using intracranial electrodes have shown that these are very frequent in the hippocampus. However, it is not known whether there is an association between hippocampal hyperexcitability and regional cerebral blood flow (rCBF). The objective of the study was to investigate the association between rCBF in hippocampus and epileptiform discharges as measured with ear-EEG in patients with Alzheimer's disease. Our hypothesis was that increased spike frequency may be associated with increased rCBF in hippocampus.

Methods

A total of 24 patients with A

SUBMITTER: Musaeus CS 

PROVIDER: S-EPMC11010418 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature