Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids.

ABSTRACT: Triterpenoids widely exist in nature, displaying a variety of pharmacological activities. Determining triterpenoids in different matrices, especially in biological samples holds great significance. High-performance liquid chromatography (HPLC) has become the predominant method for triterpenoids analysis due to its exceptional analytical performance. However, due to the structural similarities among botanical samples, achieving effective separation of each triterpenoid proves challenging, necessitating significant improvements in analytical methods. Additionally, triterpenoids are characterized by a lack of ultraviolet (UV) absorption groups and chromophores, along with low ionization efficiency in mass spectrometry. Consequently, routine HPLC analysis suffers from poor sensitivity. Chemica

SUBMITTER: Huang XF 

PROVIDER: S-EPMC11010456 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature