A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders.

ABSTRACT: Substance use disorders (SUDs) are phenotypically and genetically correlated with each other and with other psychological traits characterized by behavioural under-control, termed externalizing phenotypes. In this study, we used genomic structural equation modelling to explore the shared genetic architecture among six externalizing phenotypes and four SUDs used in two previous multivariate genome-wide association studies of an externalizing and an addiction risk factor, respectively. We first evaluated five confirmatory factor analytic models, including a common factor model, alternative parameterizations of two-factor structures and a bifactor model. We next explored the genetic correlations between factors identified in these models and other relevant psychological traits. Finally, we qu

SUBMITTER: Poore HE 

PROVIDER: S-EPMC11010459 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature