Use of pragmatic randomized trials in multiple sclerosis: A systematic overview.

ABSTRACT:

Background

Pragmatic trials are increasingly recognized for providing real-world evidence on treatment choices.

Objective

The objective of this study is to investigate the use and characteristics of pragmatic trials in multiple sclerosis (MS).

Methods

Systematic literature search and analysis of pragmatic trials on any intervention published up to 2022. The assessment of pragmatism with PRECIS-2 (PRagmatic Explanatory Continuum Indicator Summary-2) is performed.

Results

We identified 48 pragmatic trials published 1967-2022 that included a median of 82 participants (interquartile range (IQR) = 42-160) to assess typically supportive care interventions (n = 41; 85%). Only seven trials assessed drugs (15%). Only three trials (6%) included >500 participants.

SUBMITTER: Hirt J 

PROVIDER: S-EPMC11010556 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature