2.5-Year changes of connectivity dynamism are relevant for physical and cognitive deterioration in multiple sclerosis.

ABSTRACT:

Background

In MS, functional connectivity (FC) dynamism may influence disease evolution.

Objectives

The objective is to assess time-varying functional connectivity (TVFC) changes over time at 2.5-year follow-up in MS patients according to physical and cognitive worsening.

Methods

We collected 3T magnetic resonance imaging (MRI) for TVFC assessment (performed using sliding-window analysis of centrality) and clinical evaluations at baseline and 2.5-year follow-up from 28 healthy controls and 129 MS patients. Of these, 79 underwent baseline and follow-up neuropsychological assessment. At 2.5 years, physical/cognitive worsening was defined according to disability/neuropsychological score changes.

Results

At follow-up, 25/129 (19.3%) MS patients worsened physically

SUBMITTER: Rocca MA 

PROVIDER: S-EPMC11010569 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature