Emergence of OXA-48-like producing Citrobacter species, Germany, 2011 to 2022.

ABSTRACT: BackgroundCarbapenemase-producing Enterobacterales are a public health threat worldwide and OXA-48 is the most prevalent carbapenemase in Germany and western Europe. However, the molecular epidemiology of OXA-48 in species other than Escherichia coli and Klebsiella pneumoniae remains poorly understood.AimTo analyse the molecular epidemiology of OXA-48 and OXA-48-like carbapenemases in Citrobacter species (spp.) in Germany between 2011 and 2022.MethodsData of 26,822 Enterobacterales isolates sent to the National Reference Centre (NRC) for Gram-negative bacteria were evaluated. Ninety-one Citrobacter isolates from 40 German hospitals harbouring bla _{OXA-48/OXA-48‑like} were analysed by whole genome sequencing and conjugation experiments.ResultsThe

SUBMITTER: Sommer J 

PROVIDER: S-EPMC11010590 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature