Sex-Specific Expression of Histone Lysine Demethylases (KDMs) in Thyroid Cancer.

ABSTRACT:

Background

The incidence of thyroid cancer in women is 3-4-fold higher than in men. To characterize sex-specific molecular alterations in thyroid cancer, we examined the expression of sex-biased genes in normal thyroids and thyroid tumors.

Methods

Ingenuity pathways analysis was used to define sex-biased gene networks using data from the Cancer Genome Atlas (TCGA). Confirmatory studies were performed through the analysis of histone lysine demethylases (KDMs) expression by real-time PCR and immunostaining.

Results

In normal thyroids, 44 sex-biased genes were comparatively upregulated in male and 28 in female patients. The expressions of 37/72 (51%) sex-biased genes were affected in cancer tissues compared with normal thyroids. Gene network analyses revealed sex-specifi

SUBMITTER: Shobab L 

PROVIDER: S-EPMC11010840 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature