Shorter telomere length increases the risk of lymphocyte immunodeficiency: A Mendelian randomization study.

ABSTRACT:

Background

For a long time, the prevailing viewpoint suggests that shorter telomere contribute to chromosomal instability, which is a shared characteristic of both aging and cancer. The newest research presented that T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to some cancers. However, the relationship between genetically determined telomere length (TL) and immune cells remains unclear.

Methods

The two-sample Mendelian randomization analysis was conducted to elucidate the potential causal relationship. The genetic data of TL and immune cells were obtained from the Genome-Wide Association Study. The inverse variance weighted (IVW) method was used to estimate the effects primarily and another four methods were

SUBMITTER: Wang B 

PROVIDER: S-EPMC11010948 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature