Increased Pituitary Fluorine-18-Fluorodeoxyglucose Uptake in Patients with Differentiated Thyroid Cancer in Hypothyroidism versus under Recombinant Human Thyroid-Stimulating Hormone Stimulation.

ABSTRACT:

Background

¹⁸F-FDG PET/CT is performed for the assessment of radioactive iodine non-avid disease in patients with DTC. In patients prepared by THW, increased pituitary uptake of ¹⁸F-FDG in the absence of pituitary disease may reflect the physiological activation of pituitary thyrotroph cells by hypothyroidism. This study aimed to compare pituitary ¹⁸F-FDG uptake in patients with DTC under THW vs. rhTSH stimulation.

Methods

A total of 57 patients with DTC undergoing ¹⁸F-FDG PET/CT (40 under THW and 17 under rhTSH stimulation) were retrospectively analyzed. Pituitary metabolism was expressed as maximum standardized uptake value (SUVmax) and as SUVratio using the right cerebellum as reference.

Results

Pituitary hypermetabolism

SUBMITTER: Shi X 

PROVIDER: S-EPMC11011025 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature