Clinical [¹⁸F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System x_c^- Activity.

ABSTRACT:

Background

(4S)-4-(3-[¹⁸F]fluoropropyl)-L-glutamic acid ([¹⁸F]FSPG) positron emission tomography/computed tomography (PET/CT) provides a readout of system x_c^- transport activity and has been used for cancer detection in clinical studies of different cancer types. As system x_c^- provides the rate-limiting precursor for glutathione biosynthesis, an abundant antioxidant, [¹⁸F]FSPG imaging may additionally provide important prognostic information. Here, we performed an analysis of [¹⁸F]FSPG radiotracer distribution between primary tumors, metastases, and normal organs from cancer patients. We further assessed the heterogeneity of [¹⁸F]FSPG retention between cancer types, and between

SUBMITTER: Sharkey AR 

PROVIDER: S-EPMC11011143 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature