STREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury.

ABSTRACT:

Background

Malaria is an important cause of mortality in African children. Identification of biomarkers to identify children at risk of mortality has the potential to improve outcomes.

Methods

We evaluated 11 biomarkers of host response in 592 children with severe malaria. The primary outcome was biomarker performance for predicting mortality. Biomarkers were evaluated using receiver operating characteristic (ROC) curve analysis comparing the area under the ROC curve (AUROC).

Results

Mortality was 7.3% among children in the study with 72% of deaths occurring within 24 hours of admission. Among the candidate biomarkers, soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) had the highest AUROC (0.78 [95% confidence interval, .70-.86]), outperforming sever

SUBMITTER: Mufumba I 

PROVIDER: S-EPMC11011168 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature