Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster.

ABSTRACT: Blood cells in Drosophila serve primarily innate immune responses. Various stressors influence blood cell homeostasis regarding both numbers and the proportion of blood cell types. The principle molecular mechanisms governing hematopoiesis are conserved amongst species and involve major signaling pathways like Notch, Toll, JNK, JAK/Stat or RTK. Albeit signaling pathways generally rely on the activity of protein kinases, their specific contribution to hematopoiesis remains understudied. Here, we assess the role of Serine/Threonine kinases with the potential to phosphorylate the transcription factor Su(H) in crystal cell homeostasis. Su(H) is central to Notch signal transduction, and its inhibition by phosphorylation impedes crystal cell formation. Overall, nearly twenty percent of al

SUBMITTER: Deichsel S 

PROVIDER: S-EPMC11011202 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature