Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event.

ABSTRACT:

Background

Previous study consistently showed that lower serum sodium (SNa) was associated with a greater risk of mortality in hemodialysis (HD) patients. However, few studies have focused on the change in SNa (ΔSNa = post-HD SNa - pre-HD SNa) during an HD session.

Methods

In a retrospective cohort of maintenance HD adults, all-cause mortality and cardio-cerebrovascular event (CCVE) were followed up for a medium of 82 months. Baseline pre-HD SNa and ΔSNa were collected; time-averaged pre-HD SNa and ΔSNa were computed as the mean values within 1-year, 2-year and 3-year intervals after enrollment. Cox proportional hazards models were used to evaluate the relationships of pre-HD and ΔSNa with outcomes.

Results

Time-averaged pre-HD SNa were associated with all-cause morta

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11011235 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature