IL-17RA Signaling in Prx1+ Mesenchymal Cells Influences Fracture Healing in Mice.

ABSTRACT: Fracture healing is a complex series of events that requires a local inflammatory reaction to initiate the reparative process. This inflammatory reaction is important for stimulating the migration and proliferation of mesenchymal progenitor cells from the periosteum and surrounding tissues to form the cartilaginous and bony calluses. The proinflammatory cytokine interleukin (IL)-17 family has gained attention for its potential regenerative effects; however, the requirement of IL-17 signaling within mesenchymal progenitor cells for normal secondary fracture healing remains unknown. The conditional knockout of IL-17 receptor a (Il17ra) in mesenchymal progenitor cells was achieved by crossing Il17ra^F/F mice with Prx1-cre mice to generate Prx1-cre; Il1

SUBMITTER: Roberts JL 

PROVIDER: S-EPMC11011315 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature