Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts.

ABSTRACT: Cohesin is a highly conserved ring-shaped complex involved in topologically embracing chromatids, gene expression regulation, genome compartmentalization, and genome stability maintenance. Genomic analyses have detected mutations in the cohesin complex in a wide array of human tumors. These findings have led to increased interest in cohesin as a potential target in cancer therapy. Synthetic lethality has been suggested as an approach to exploit genetic differences in cancer cells to influence their selective killing. In this study, we show that mutations in ESCO1, NIPBL, PDS5B, RAD21, SMC1A, SMC3, STAG2, and WAPL genes are synthetically lethal with stimulation of WNT signaling obtained following LY2090314 treatment, a GSK3 inhibitor,

SUBMITTER: Pallotta MM 

PROVIDER: S-EPMC11011321 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature