Single high-energy arc proton therapy with Bragg peak boost (SHARP).

ABSTRACT:

Introduction

Because of the co-location of critical organs at risk, base of skull tumours require steep dose gradients to achieve the prescribed dosimetric criteria. When available, proton beam therapy (PBT) is often considered a desirable modality for these cases, but in many instances, compromises in target coverage are still required to achieve critical organ at risk (OAR) tolerance doses. A number of techniques have been proposed to further improve the penumbra of PBT. In the current study, we propose a novel, collimator-free treatment planning technique that combines high-energy shoot-through proton beams with conventional Bragg peak spot placement. The small spot size of the high-energy pencil beams provides a sharp penumbra at the target boundary, and the Bragg peak spots pr

SUBMITTER: Penfold SN 

PROVIDER: S-EPMC11011576 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature