<i>IGF-1</i> rs6218 polymorphisms modulate the susceptibility to age-related cataract.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs), as the most abundant form of DNA variation in the human genome, contribute to age-related cataracts (ARC) development. Apoptosis of lens epithelial cells (LECs) is closely related to ARC formation. Insulin-like growth factor 1 (IGF1) contributes to cell apoptosis regulation. Moreover, IGF1 was indicated to exhibit a close association with cataract formation. Afterward, an investigation was conducted to examine the correlation between polymorphisms in IGF1 and the susceptibility to ARC.

Methods

The present investigation was a case-control study. Venous blood draws were collected from the participants for DNA genotyping. Lens capsule samples were collected to detect mRNA and apoptosis. TaqMan RT-PCR was used to detect <

SUBMITTER: Zou X 

PROVIDER: S-EPMC11011587 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature