Paternal Age Amplifies Cryopreservation-Induced Stress in Human Spermatozoa.

ABSTRACT: The global fall in male fertility is a complicated process driven by a variety of factors, including environmental exposure, lifestyle, obesity, stress, and aging. The availability of assisted reproductive technology (ART) has allowed older couples to conceive, increasing the average paternal age at first childbirth. Advanced paternal age (APA), most often considered male age ≥40, has been described to impact several aspects of male reproductive physiology. In this prospective cohort study including 200 normozoospermic patients, 105 of whom were ≤35 years (non-APA), and 95 of whom were ≥42 years (APA), we assessed the impact of paternal age on different endpoints representative of sperm quality and cryopreservation tolerance. Non-APA patients had superior fresh semen quality; DNA fragmenta

SUBMITTER: Perez Casasus S 

PROVIDER: S-EPMC11011712 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature