MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications.

ABSTRACT: Pancreatic cancer remains a formidable malignancy characterized by high mortality rates, primarily attributable to late-stage diagnosis and a dearth of effective therapeutic interventions. The identification of reliable biomarkers holds paramount importance in enhancing early detection, prognostic evaluation, and targeted treatment modalities. Small non-coding RNAs, particularly microRNAs, have emerged as promising candidates for pancreatic cancer biomarkers in recent years. In this review, we delve into the evolving role of cellular and circulating miRNAs, including exosomal miRNAs, in the diagnosis, prognosis, and therapeutic targeting of pancreatic cancer. Drawing upon the latest research advancements in omics data-driven biomarker discovery, we also perform a case study using public da

SUBMITTER: Madadjim R 

PROVIDER: S-EPMC11011772 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature