[Cu(NN₁)₂]ClO₄, a Copper (I) Complex as an Antimicrobial Agent for the Treatment of Piscirickettsiosis in Atlantic Salmon.

ABSTRACT: Piscirickettsia salmonis is the pathogen that most affects the salmon industry in Chile. Large quantities of antibiotics have been used to control it. In search of alternatives, we have developed [Cu(NN₁)₂]ClO₄ where NN₁ = 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one. The antibacterial capacity of [Cu(NN₁)₂]ClO₄ was determined. Subsequently, the effect of the administration of [Cu(NN₁)₂]ClO₄ on the growth of S. salar, modulation of the immune system and the intestinal microbiota was studied. Finally, the ability to protect against a challenge with P. salmonis was evaluated. The results obtained showed that the compound has an MIC between 15 and 33.9 μg/mL

SUBMITTER: Parra M 

PROVIDER: S-EPMC11011784 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature