Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity.

ABSTRACT: In this study, binary amorphous solid dispersions (ASDs, fisetin-Eudragit^®) and ternary amorphous solid inclusions (ASIs, fisetin-Eudragit^®-HP-β-cyclodextrin) of fisetin (FIS) were prepared by the mechanochemical method without solvent. The amorphous nature of FIS in ASDs and ASIs was confirmed using XRPD (X-ray powder diffraction). DSC (Differential scanning calorimetry) confirmed full miscibility of multicomponent delivery systems. FT-IR (Fourier-transform infrared analysis) confirmed interactions that stabilize FIS's amorphous state and identified the functional groups involved. The study culminated in evaluating the impact of amorphization on water solubility and conducting in vitro antioxidant assays: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)-ABTS, 2,

SUBMITTER: Rosiak N 

PROVIDER: S-EPMC11011862 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature