DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App^N-LF Mice and Influences Presymptomatic Pathology.

ABSTRACT: At the time of diagnosis, Alzheimer's disease (AD) patients already suffer from significant neuronal loss. The identification of proteins that influence disease progression before the onset of symptoms is thus an essential part of the development of new effective drugs and biomarkers. Here, we used an unbiased ¹⁸O labelling proteomics approach to identify proteins showing altered levels in the AD brain. We studied the relationship between the protein with the highest increase in hippocampus, DEAD box Helicase 24 (DDX24), and AD pathology. We visualised DDX24 in the human brain and in a mouse model for Aβ42-induced AD pathology-App^NL-F-and studied the interaction between Aβ and DDX24 in primary neurons. Immunohistochemistry in the AD brain confirmed the increase

SUBMITTER: Axenhus M 

PROVIDER: S-EPMC11011903 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature