Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.

ABSTRACT: Research into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor. Over the years, FcRn has been shown to function not only as a receptor that transfers immunity from mother to fetus but also performs an array of different functions that include transport and recycling of immunoglobulins and albumin in the adult. Due to its important cellular roles, several clinical trials have been designed to either inhibit/enhance FcRn function or develop of non-invasive therapeutic delivery system such as fusion of drugs to IgG Fc or albumin to enhance delivery inside the cells. Here, we report the accidental identification of several FcRn alternatively spliced variants in both mouse and human cells. The four new mouse s

SUBMITTER: Haddad G 

PROVIDER: S-EPMC11012118 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature