The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs.

ABSTRACT: The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated secretory phenotype (SASP), which may regulate tumorigenesis. Senolytic therapy is considered a novel anticancer strategy that eliminates the deleterious effects of senescent cells in the TME. Here, we show that two different types of senolytic drugs, despite efficiently depleting senescent cells, have opposite effects on cancer-associated fibroblasts (CAFs) and their ability to regulate epithelial-mesenchymal transition (EMT). We found that senolytic drugs, navitoclax and the combination of dasatinib/quercetin, reduced the number of spontaneously senescen

SUBMITTER: Bogdanova DA 

PROVIDER: S-EPMC11012227 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature